MYELOID NEOPLASIA Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
نویسندگان
چکیده
1Department of Internal Medicine/Hematology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; 2Inserm, Unité 892, Angers, France; 3Service des Maladies du Sang, Centre Hospitalier Universitaire, Angers, France; 4Institute for Biomedicine and Nutrition, NOVUM, Karolinska Institutet, Stockholm, Sweden; 5Department of Internal Medicine III, University Hospital, Ulm, Germany; 6Laboratoire d Hematologie, Centre Hospitalier Universitaire, Angers, France; 7Department of Hematology, Örebro University Hospital, Örebro, Sweden; and 8Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
منابع مشابه
Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.
Cytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and 50% of all adult acute myeloid leukemia (AML) cases. In this clinically diverse group, molecular aberrations, such as FLT3-ITD, NPM1, and CEBPA mutations, recently have added to the prognostic accuracy. Aberrant DNA methylation is a hallmark of cancer, including AML. We investigated in total 118 CN-AML samples in a t...
متن کاملPrognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks Short title: Profile of prognostic DNA methylation in AML
Institutions: Department of Internal Medicine / Hematology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Institut National de la Santé et de la Recherche Médicale, Unité 892, Angers, France; Service des Maladies du Sang, Centre Hospitalier Universitaire, Angers, France; Institute for Biomedicine and Nutrition, NOVUM, Karolinska Institutet, Stockholm, Sweden...
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